商锦赛，JINSAI SHANG, Ph.D. (PI)
2021-Present: Guangzhou Laboratory, PI (广州实验室, 研究员)
2020-2021: GRMH-GDL, PI (生物岛实验室神经代谢与再生研究中心, 研究员)
2015-2020: The Scripps Research Institute, Postdoc (斯克利普斯研究所, 博士后)
2010-2015: SIU-Carbondale, Ph.D. (南伊利诺伊大学, 生物化学, 博士)
2006-2010: Wuhan University, B.S. (武汉大学, 理学学士, 化学基地班)
研究领域：药物靶标激素核受体(NRs)与G蛋白偶联受体(GPCRs)的结构与功能；靶向抗糖尿病与抗肿瘤等新药小分子开发与作用机制；高通量筛选孤儿受体的活性化合物及其构效关系；靶向药物小分子设计与优化。结合生物物理，结构生物学，细胞生物学等方法深入研究药物小分子与相关受体的分子作用机制并应用于基于结构的药物研发。
Jinsai Shang obtained a B.S degree (Chemistry) in 2006 from Wuhan University and completed a Ph.D. degree in 2015 at the Southern Illinois University-Carbondale (SIU-Carbondale) studying biophysics (structural biology using X-ray crystallography and NMR). In Aug 2015, he joined the laboratory of Douglas Kojetin at Scripps Research Institute, where he investigated how synthetic/natural ligands target nuclear receptors including a well-known antidiabetic drug target PPARγ (Peroxisome proliferator-activated receptor-gamma) and studied the structural mechanism of ligand-induced graded receptor transcriptional activation and repression to benefit structure-guided drug discovery. Dr. Shang joined the Center for Neuro-Metabolism and Regeneration Research (CNMR) at Guangzhou Regenerative Medicine and Heath Guangdong Laboratory (GRMH-GDL) as a principal investigator in 2020. The lab was transferred to Guangzhou Laboratory (GZL) in the spring of 2021.
E-mail: [email protected]